Hepatobiliary and Pancreatic: Sinusoidal obstruction syndrome during chemotherapy

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Sinusoidal obstruction syndrome after oxaliplatin-based chemotherapy

Drug-induced liver injury presents with extremely diverse histologic patterns, including necroinflammatory, cholestatic, steatotic and vascular patterns. Sinusoidal obstruction syndrome (SOS), also referred to as toxic sinusoidal injury, veno-occlusive disease or “blue liver syndrome”, is a commonly recognized vascular pattern of drug-induced liver injury, and has been frequently associated wit...

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Regorafenib suppresses sinusoidal obstruction syndrome in rats.

BACKGROUND Sinusoidal obstruction syndrome (SOS), a form of drug-induced liver injury related to oxaliplatin treatment, is associated with postoperative morbidity after hepatectomy. This study aimed to examine the impact of regorafenib, the first small-molecule kinase inhibitor to show efficacy against metastatic colorectal cancer, on a rat model of SOS. METHODS Rats with monocrotaline (MCT)-...

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Tusanqi-Related Sinusoidal Obstruction Syndrome in China

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Hepatic Sinusoidal Obstruction Syndrome During Chemotherapy for Childhood Medulloblastoma: Report of a Case and Review of the Literature

Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease, is a well-recognized toxic complication after autologous and allogeneic hematopoietic stem cell transplant, during treatment of Wilms tumor and rhabdomyosarcoma associated with actinomycin-D, and during acute lymphoblastic leukemia therapy due to oral 6-thioguanine. However, its occurrence in the context of ch...

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focal sinusoidal obstruction syndrome caused by oxaliplatin-induced chemotherapy: a case report

conclusions atypical irregular tumors should be considered as sos when the patient has received oxaliplatin-based chemotherapy. a qualitative imaging modality diagnosis, such as with diffusion-weighted mri, is superior to a morphological diagnosis in focal sos. this imaging modality can prevent unnecessary operations. case presentation a 40-year-old woman with rectal cancer underwent high anter...

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ژورنال

عنوان ژورنال: Journal of Gastroenterology and Hepatology

سال: 2011

ISSN: 0815-9319

DOI: 10.1111/j.1440-1746.2011.06753.x